Will ddr3 ram work with a ddr4 motherboard

Can we put DDR4 ram in DDR3 Slot or DDR3 1600Mhz ddr3 slot
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ddr3 vs ddr4 slot If your MacPC requires DDR3 , you may use DDR3 or DDR3L If you mix DDR3 and DDR3L, put DDR3 in the first slot (find